Brandon Aiyuk (shoulder) practiced on Friday.

29 September 2023

Aiyuk has been limited in every practiced throughout the week and has a good chance of playing in Week 4 against the Cardinals. Aiyuk’s return could be crucial for the 49ers, as Deebo Samuel (ribs/knee) has yet to practice this week and is at risk of missing the game. Aiyuk could operate as the 49ers WR1 if he’s active and Samuel is held out, which should be enough to lock him in as a top-24 play this week.