NFL Network’s Ian Rapoport reports the Cardinals are “preparing for Jacoby Brissett to start” in Week 6 against the Colts.

12 October 2025

Per Rapoport, Murray’s mid-foot sprain is a “version of a Lisfranc injury.” He added that it’s possible Kyler misses more than just Week 6. Murray missed the first two practices of the week before returning on Friday. He was listed as questionable after getting in a limited session. Brissett took the bulk of the reps with the starters in practice this week and Murray’s foot issue could worsen if he tries to play through it. We fully expect to see Brissett under center versus Indy. Brissett is nothing more than a QB2 for fantasy purposes, but he could boost Marvin Harrison Jr.'s fantasy outlook with a more aggressive style as a passer.