49ers declared QB Brock Purdy, WR Jauan Jennings, WR Ricky Pearsall, RB Jordan James, WR Jordan Watkins, DL Robert Beal and LB Nick Martin inactive for Week 5 against the Rams.

02 October 2025

Losing Purdy, Jennings (ankle, ribs) and Pearsall (knee) for a Thursday night divisional showdown is brutal. The 49ers, Rams and Seahawks sit in a three-way tie for first place in the NFC West with 3-1 records. Fantasy managers should expect Christian McCaffrey to handle a significant workload in this one. Kendrick Bourne and Demarcus Robinson will serve as the Nos. 1 and 2 wide receivers, respectively. 49ers TE Jake Tonges has comparatively earned targets moderately efficiently in his role as a fill-in starter. Mac Jones is a viable starter in two-quarterback leagues.