49ers ruled out QB Brock Purdy (toe) for Week 5 against the Rams.

01 October 2025

The 49ers will also be without WR Jauan Jennings (ankle/ribs) and WR Ricky Pearsall (knee). All three failed to practice this week. Backup QB Mac Jones (knee) promisingly practiced in full every day. In Jones’ two prior starts this season, he completed 53-of-80 passes for 563 yards, four touchdowns and one interception and rushed seven times for five yards. He belongs on the QB2 radar against the Rams on Thursday night.